Tablet Presentation

Each tablet contains:
Ketorolac 10 mg

It belongs to the class of non-steroidal anti-inflammatory drug. It has various properties such as antipyretic, analgesic and anti-inflammatory. It shows similar potential to that opioid analgesic i.e. morphine.

Indications & Usage

• Rheumatoid arthritis
• Osteoarthritis
• Menstrual disorders
• Headaches
• Ankylosing spondylitis

Mechanism of Action

Ketorolac inhibits the prostaglandin synthesis by inhibiting cyclooxygenase 1 and cyclooxygenase enzyme. Ketorolac shows maximum binding with cox-2 thus inhibits inflammation and pain mediated by prostaglandins.

Pharmacokinetics

Absorption: It is absorbed rapidly by oral administration
Protein Binding: It is highly bound to proteins
Metabolism: It undergoes hydroxylation and conjugation in the liver
Excretion: It is excreted via urine

Side Effects

• Diarrhoea
• Dizziness
• Headache
• Nausea
• Abdominal cramps
• Irritation
• Drowsiness

Contraindications

• Contraindicated in chronic heart failure
• Contraindicated in haemorrhage in brain

Drug Interactions

• Acetaminophen
• Lorazepam
• Dexamethasone
• Diclofenac

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